methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

Base Information

Chemical Name:methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate
CAS No.:1346134-55-1
Molecular Formula:C₄₂H₄₂N₄O₈S₂
Molecular Weight:794.949
Hs Code.:

methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

Synonyms:methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

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Chemical Property of methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

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Technology Process of methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

There total 11 articles about methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346136-06-8
methyl 4-[2-(4-{[(2-amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate

: 1346136-35-3
3-{[5-(methoxycarbonyl)pyridin-2-yl](propyl)sulfamoyl}benzoic acid

: 1346134-55-1
methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 1346136-14-8
3-(chlorosulfonyl)benzoic acid 2-(trimethylsilyl)ethyl

: 1346134-55-1
methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; dmap / dichloromethane / 14 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 1346134-55-1
methyl 6-[{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}(propyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / methanol / 16 h / 20 °C / Cooling with ice

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; N,N-dimethyl-formamide; water / 8 h / 20 °C / 760.05 Torr

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

4: morpholine / toluene / 4 h / 120 °C / Reflux; Dean-Stark

5: sulfur; morpholine / N,N-dimethyl-formamide / 1 h / 50 °C

6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

With morpholine; palladium 10% on activated carbon; hydrogen; sodium methylate; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;