Technology Process of 2-(naphthalen-2-ylmethyl)-1-(phenylsulfonyl)-1H-indole-5-carbonitrile
There total 3 articles about 2-(naphthalen-2-ylmethyl)-1-(phenylsulfonyl)-1H-indole-5-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-benzenesulfonyl-1H-indole-5-carbonitrile;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -48 - -30 ℃;
for 1.05h;
Inert atmosphere;
2-bromomethylnaphthyl bromide;
In
tetrahydrofuran; pentane;
at -45 - 20 ℃;
for 26.7833h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 25 h / 20 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; pentane / Inert atmosphere; Cooling
2.2: Inert atmosphere; Cooling
With
tetrabutylammomium bromide; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; water; toluene; pentane;
DOI:10.1039/c0ob00146e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 25 h / 20 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; pentane / Inert atmosphere; Cooling
2.2: Inert atmosphere; Cooling
With
tetrabutylammomium bromide; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; water; toluene; pentane;
DOI:10.1039/c0ob00146e
