1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

Base Information

Chemical Name:1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one
CAS No.:1309831-22-8
Molecular Formula:C₂₆H₃₅F₄N₉O₂
Molecular Weight:581.617
Hs Code.:

1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

Synonyms:1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

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Chemical Property of 1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

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Technology Process of 1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

There total 5 articles about 1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845820-42-0
2-Chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine

: 1309831-21-7
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

: 1309831-22-8
1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: With toluene-4-sulfonic acid; In isopropyl alcohol; Reflux;

Reference yield:

: 1309833-25-7
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

: 1309831-22-8
1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

2: toluene-4-sulfonic acid / isopropyl alcohol / Reflux

With hydrogen; toluene-4-sulfonic acid; palladium 10% on activated carbon; In methanol; isopropyl alcohol;

Reference yield:

: 1309831-35-3
1-(2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

: 1309831-22-8
1-(5-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2-ylamino)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)phenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 2.08 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

3.1: toluene-4-sulfonic acid / isopropyl alcohol / Reflux

With hydrogen; potassium hydride; toluene-4-sulfonic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; isopropyl alcohol; mineral oil;