1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Base Information

Chemical Name:1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one
CAS No.:1309831-21-7
Molecular Formula:C₁₂H₁₄F₃N₅O₂
Molecular Weight:317.271
Hs Code.:

Synonyms:1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

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Chemical Property of 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

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Technology Process of 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

There total 4 articles about 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309833-25-7
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

: 1309831-21-7
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 1h;

Reference yield:

: 1309831-35-3
1-(2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

: 1309831-21-7
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 2.08 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With hydrogen; potassium hydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; mineral oil;

Reference yield:

: 68622-14-0
1-Fluoro-2-isocyanato4-nitro-benzene

: 1309831-21-7
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)-5-aminophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilylazide / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: potassium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

3.2: 2.08 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With trimethylsilylazide; hydrogen; potassium hydride; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;