6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline

Base Information

• Chemical Name: 6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline
• CAS No.: 179688-72-3
• Molecular Formula: C₂₂H₂₁N₅O₂
• Molecular Weight: 387.441
• Mol file: 179688-72-3.mol

Synonyms:6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline

Chemical Property of 6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline

There total 1 articles about 6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

7-chloro-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]-6-nitroquinazoline → 6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline (179688-72-3) + 7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]-6-nitroquinazoline

Guidance literature:

With sodium methylate; In dimethyl sulfoxide;

Reference yield: 85.0%

6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline (179688-72-3) + ethoxyethoxyethanol (111-90-0) + 2-Amino-4-chlorobenzoic acid (89-77-0) → 7-chloroquinazolin-4(1H)-one (31374-18-2)

Guidance literature:

With formamide;

Reference yield:

4-(3,3-dimethoxy-propyl)-morpholine (22098-88-0) + 6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline (179688-72-3) → 7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]-6-(3-morpholinopropylamino)quinazoline, trihydrochloride salt

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In ethanol; water; acetic acid; ethyl acetate;

Downstream raw materials:

7-chloroquinazolin-4(1H)-one