(3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Base Information

Chemical Name:(3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole
CAS No.:201863-42-5
Molecular Formula:C₂₆H₃₂O₆
Molecular Weight:440.536
Hs Code.:

Synonyms:(3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

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Chemical Property of (3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

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Technology Process of (3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

There total 7 articles about (3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100-39-0
benzyl bromide

: 201863-41-4
(R)-[(3aR,4R,6R,6aS)-6-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-phenyl-methanol

: 201863-42-5
(3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 201863-42-5
(3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg / 1.) THF, 2.) 0 deg C, 3 h

2: 79 percent / PDC, 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 50 °C

3: 80 percent / NaBH₄ / methanol / 0.5 h / -10 °C

4: 86 percent / NaH / dimethylformamide / 1 h / Ambient temperature

With sodium tetrahydroborate; dipyridinium dichromate; 4 A molecular sieve; sodium hydride; magnesium; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 7757-38-2,14131-84-1,23262-78-4,27108-13-0,33823-04-0,34685-42-2,57819-52-0,78039-08-4,78039-12-0,78964-16-6,94842-76-9,149342-31-4
2,3,5,6-di-O-isopropylidene-D-mannofuranose

: 201863-42-5
(3aR,4R,6R,6aS)-4-((R)-Benzyloxy-phenyl-methyl)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) t-BuOK / 1.) DMSO, 10 deg C, 30 min, 2.) DMSO, r.t., 30 min

2: 1.) oxalyl dichloride, DMSO, 2.) TEA / 1.) CH₂Cl₂, - 78 deg C, 45 min, 2.) -78 deg C to r.t.

3: 1.) Mg / 1.) THF, 2.) 0 deg C, 3 h

4: 79 percent / PDC, 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 50 °C

5: 80 percent / NaBH₄ / methanol / 0.5 h / -10 °C

6: 86 percent / NaH / dimethylformamide / 1 h / Ambient temperature

With sodium tetrahydroborate; dipyridinium dichromate; oxalyl dichloride; 4 A molecular sieve; TEA; potassium tert-butylate; sodium hydride; magnesium; dimethyl sulfoxide; In methanol; dichloromethane; N,N-dimethyl-formamide;