N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester

Base Information

• Chemical Name: N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester
• CAS No.: 120008-85-7
• Molecular Formula: C₄₅H₆₆N₄O₉
• Molecular Weight: 807.04
• Mol file: 120008-85-7.mol

Synonyms:N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester

Chemical Property of N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester

There total 8 articles about N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysine (129297-31-0) + proline tert-butyl ester (2812-46-6) → Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester (120008-85-7)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; for 3h;

Reference yield:

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (63628-63-7) → Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester (120008-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 44 percent / Et₃N, KI / acetonitrile / 72 h / Heating

2: 85 percent / 99percent formic acid / 30 h / 40 °C

3: 96 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 3 h

With formic acid; diethyl cyanophosphonate; triethylamine; potassium iodide; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (63628-63-7) → 4-{(R)-6-[(S)-5-Benzyloxycarbonylamino-1-((S)-2-tert-butoxycarbonyl-pyrrolidine-1-carbonyl)-pentylamino]-6-ethoxycarbonyl-hexyl}-piperidine-1-carboxylic acid benzyl ester (120008-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent / Et₃N, KI / acetonitrile / 72 h / Heating

2: 99percent formic acid / 30 h / 40 °C

3: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 3 h

With formic acid; diethyl cyanophosphonate; triethylamine; potassium iodide; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

4-[(R)-6-((S)-5-Benzyloxycarbonylamino-1-carboxy-pentylamino)-6-ethoxycarbonyl-hexyl]-piperidine-1-carboxylic acid benzyl ester

proline tert-butyl ester

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester

ethyl 7-(1-benzyloxycarbonyl-4-piperidyl)-2-chloroheptanoate