tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

Base Information

Chemical Name:tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate
CAS No.:1303588-41-1
Molecular Formula:C₂₂H₂₅ClN₂O₃
Molecular Weight:400.905
Hs Code.:

Synonyms:tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

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Chemical Property of tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

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Technology Process of tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

There total 1 articles about tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1303588-39-7
tert-butyl 2-(3-chlorophenyl)-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

: 74-88-4
methyl iodide

: 1303588-41-1
tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

Guidance literature:: tert-butyl 2-(3-chlorophenyl)-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate; With potassium tert-butylate; In tetrahydrofuran; at -40 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -40 - 20 ℃; for 3h;

Reference yield: 99.0%

: 1303588-41-1
tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

: 1303588-42-2
2-(3-chlorophenyl)-6,6-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-5-one

Guidance literature:: tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate; With hydrogenchloride; In methanol; at 20 ℃;

With sodium hydrogencarbonate; In water; pH=10;

Reference yield:

: 1303588-41-1
tert-butyl 2-(3-chlorophenyl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

: 1303587-05-4
2-(3-chlorophenyl)-N-(3-fluoropyridin-4-yl)-6,6-dimethyl-5-oxo-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol / 20 °C

1.2: pH 10

2.1: triethylamine / tetrahydrofuran / 20 h / 50 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In tetrahydrofuran; methanol;