Technology Process of di-(S-acetyl-2-thioethyl)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonate
There total 8 articles about di-(S-acetyl-2-thioethyl)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole / dichloromethane / 2.67 h / 10 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; water / 4 h / -73 - -70 °C
2.2: 1.08 h / -73 - -70 °C
3.1: n-butyllithium / tetrahydrofuran / 1.75 h / -75 - -70 °C
3.2: 3 h / -75 - -70 °C
4.1: hydrogen / palladium 10% on activated carbon / acetic acid; ethyl acetate / 3 h / 20 °C
5.1: tetraethylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
5.2: 0.25 h
6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C
6.2: 16 h / 0 - 20 °C
7.1: trimethylsilyl bromide / dichloromethane / 0.25 h / -30 °C
8.1: pyridine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 16 h / 70 °C
With
pyridine; 1H-imidazole; n-butyllithium; trimethylsilyl bromide; hydrogen; sodium hydride; tetraethylammonium fluoride; dicyclohexyl-carbodiimide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / 1.75 h / -75 - -70 °C
1.2: 3 h / -75 - -70 °C
2.1: hydrogen / palladium 10% on activated carbon / acetic acid; ethyl acetate / 3 h / 20 °C
3.1: tetraethylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3.2: 0.25 h
4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C
4.2: 16 h / 0 - 20 °C
5.1: trimethylsilyl bromide / dichloromethane / 0.25 h / -30 °C
6.1: pyridine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 16 h / 70 °C
With
pyridine; n-butyllithium; trimethylsilyl bromide; hydrogen; sodium hydride; tetraethylammonium fluoride; dicyclohexyl-carbodiimide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
