1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

Base Information

Chemical Name:1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid
CAS No.:925684-32-8
Molecular Formula:C₃₂H₄₀FN₃O₁₂P₂
Molecular Weight:739.628
Hs Code.:

1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

Synonyms:1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

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Chemical Property of 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

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Technology Process of 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

There total 4 articles about 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925684-97-5
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bis(diethylphosphono)butoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

: 925684-32-8
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; for 27h; Inert atmosphere;
DOI:10.1021/jm801007z

Reference yield:

: 925684-96-4
1-(4-(4,4-bis(diethylphosphono)butoxy)phenyl)prop-2-en-1-one

: 925684-32-8
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dmap / dichloromethane / 20 h / 20 °C

2.1: trimethylsilyl bromide / dichloromethane / 26.5 h

2.2: pH 8

With trimethylsilyl bromide; triethylamine; dmap; In dichloromethane;

Reference yield:

: 95605-38-2
1-(4-hydroxyphenyl)prop-2-en-1-one

: 925684-32-8
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 6.5 h / Heating / reflux

2.1: triethylamine / dmap / dichloromethane / 20 h / 20 °C

3.1: trimethylsilyl bromide / dichloromethane / 26.5 h

3.2: pH 8

With trimethylsilyl bromide; potassium carbonate; triethylamine; dmap; In dichloromethane; acetone;