925684-97-5

Upstream product

• 925684-96-4 1-(4-(4,4-bis(diethylphosphono)butoxy)phenyl)prop-2-en-1-one 
• 160738-57-8 gatifloxacin 
• 1660-94-2 Tetraethyl methylenediphosphonate 
• 925684-41-9 tetraethyl 4-iodobutylene-1,1-bisphosphonate 
• 95605-38-2 1-(4-hydroxyphenyl)prop-2-en-1-one 
• 99-93-4 4-Hydroxyacetophenone 
• 150250-34-3 tetraethyl 4-hydroxybutylene-1,1-bisphosphonate 
• 150250-33-2 tetraethyl 4-(tetrahydro-2H-pyran-2-yloxy)butylene-1,1-bisphosphonate 

Downstream Products

• 925684-32-8 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bisphosphonobutoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections

The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and/or the treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis.

Linking bisphosphonates to the free amino groups in fluoroquinolones: Preparation of osteotropic prodrugs for the prevention of osteomyelitis

Osteomyelitis is an infection located in bone and a notoriously difficult disease to manage, requiring frequent and heavy doses of systemically administered antibiotics. Targeting antibiotics to the bone after systemic administration may provide both grea