(E)-4,4-difluoro-5-phenyl-2-pentenol

Base Information

Chemical Name:(E)-4,4-difluoro-5-phenyl-2-pentenol
CAS No.:503560-25-6
Molecular Formula:C₁₁H₁₂F₂O
Molecular Weight:198.212
Hs Code.:

Synonyms:(E)-4,4-difluoro-5-phenyl-2-pentenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4,4-difluoro-5-phenyl-2-pentenol

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Technology Process of (E)-4,4-difluoro-5-phenyl-2-pentenol

There total 3 articles about (E)-4,4-difluoro-5-phenyl-2-pentenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 424835-89-2
ethyl (E)-4,4-difluoro-5-phenylpent-2-enoate

: 503560-25-6
(E)-4,4-difluoro-5-phenyl-2-pentenol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1016/j.tet.2005.04.034

Reference yield:

: 875030-90-3
2,2-difluoro-3-phenyl-propionaldehyde

: 503560-25-6
(E)-4,4-difluoro-5-phenyl-2-pentenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.17 h / 0 °C

1.2: 310 mg / tetrahydrofuran / 1 h / 0 °C

2.1: 100 percent / DIBAL-H / hexane; tetrahydrofuran / 1 h / -78 °C

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; 1.1: Horner-Emmons reaction;
DOI:10.1016/j.tet.2005.04.034

Reference yield:

: 134806-69-2
ethyl 2,2-difluoro-3-phenylpropionate

: 503560-25-6
(E)-4,4-difluoro-5-phenyl-2-pentenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: NaH / tetrahydrofuran / 0.17 h / 0 °C

2.2: 310 mg / tetrahydrofuran / 1 h / 0 °C

3.1: 100 percent / DIBAL-H / hexane; tetrahydrofuran / 1 h / -78 °C

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; 2.1: Horner-Emmons reaction;
DOI:10.1016/j.tet.2005.04.034