875030-90-3Relevant academic research and scientific papers
Rapid, general access to chiral β-fluoroamines and β,β-difluoroamines via organocatalysis
Fadeyi, Olugbeminiyi O.,Lindsley, Craig W.
supporting information; experimental part, p. 943 - 946 (2009/08/07)
A rapid, general route to enantiopure β-fluoroamines and β,β-difluoroamines has been developed employing organocatalysis in both a twopot and a one-pot procedure. Both chemical yields (64-82%) and enantioselectivity (94-98% ee) were excellent and represen
Enantioselective formation of stereogenic carbon - Fluorine centers by a simple catalytic method
Marigo, Mauro,Fielenbach, Doris,Braunton, Alan,Kjaersgaard, Anne,Jorgensen, Karl Anker
, p. 3703 - 3706 (2007/10/03)
(Chemical Equation Presented) An easy protocol has been developed for the formation of stereogenic carbon-fluorine centers by the organocatalytic asymmetric α-fluorination of aldehydes 1. The 2-fluoroaldehydes 4 are formed with 2 as the fluorinating agent
Stereoselective synthesis of (Z)-fluoroalkenes directed to peptide isosteres: Copper mediated reaction of trialkylaluminum with 4,4-difluoro-5-hydroxyallylic alcohol derivatives
Nakamura, Yuko,Okada, Midori,Sato, Azusa,Horikawa, Hiroaki,Koura, Minoru,Saito, Akio,Taguchi, Takeo
, p. 5741 - 5753 (2007/10/03)
Copper mediated alkyl-transfer reaction of trialkylaluminum (R 3Al) with (E)-4,4-difluoro-5-hydroxyallylic alcohol derivative smoothly proceeded to give the corresponding 2-alkylated 4-fluoro-5- hydroxyhomoallylic alcohol derivative with comple
