C₂₆H₃₁F₃O₈

Base Information

• Chemical Name: C₂₆H₃₁F₃O₈
• CAS No.: 131103-12-3
• Molecular Formula: C₂₆H₃₁F₃O₈
• Molecular Weight: 528.523
• Mol file: 131103-12-3.mol

Synonyms:C₂₆H₃₁F₃O₈

Chemical Property of C₂₆H₃₁F₃O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₁F₃O₈

There total 39 articles about C₂₆H₃₁F₃O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → C26H31F3O8 (131103-12-3)

Guidance literature:

Multi-step reaction with 15 steps

1: 100 percent / p-TsOH*H₂O / benzene / 1 h / Heating

2: 91 percent / pyridinium bromide perbromide / tetrahydrofuran / 0.25 h / Ambient temperature

3: 77 percent / t-BuOK / dimethylsulfoxide / 0.25 h / Ambient temperature

4: 1.) t-BuLi, 2.) HMPA / 1.) THF, pentane, 0 deg C, 1 h, 2.) THF, pentane, -78 deg C, 30 min

5: oxalic acid / CH₂Cl₂ / 2 h / Ambient temperature

6: (COCl)2, DMSO / CH₂Cl₂ / 0.5 h / -78 °C

7: ZnBr₂ / CH₂Cl₂ / 23 h / Ambient temperature

8: camphorsulfonic acid (CSA) / benzene / 18 h / Ambient temperature

9: 79 percent / dimethylsulfoxide; tetrahydrofuran / 1.75 h / 0 - 20 °C

10: 217 mg / H₂ / 10percent Pd/C / methanol / 0.75 h / Ambient temperature

11: NaIO₄, RuO₂ / H₂O; CCl₄; acetonitrile / 1.5 h / 0 - 20 °C

12: diethyl ether / 0 °C

14: 82 percent / NaBH₄ / methanol; tetrahydrofuran / 0.5 h / -20 °C

15: 4-(N,N-dimethylamino)pyridine (DMAP), unsym-N,N-dimethylethylenediamine / pyridine / 14.25 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; oxalyl dichloride; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; tert.-butyl lithium; pyridinium hydrobromide perbromide; oxalic acid; toluene-4-sulfonic acid; dimethyl sulfoxide; N,N-dimethylethylenediamine; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetonitrile; benzene;

Reference yield:

1,5-dichloropentan-3-one (3592-25-4) → C26H31F3O8 (131103-12-3)

Guidance literature:

Multi-step reaction with 16 steps

1: 35 percent / aq. NaH₂PO₄, o-H₃PO₄ / 3 h / 100 °C

2: 100 percent / p-TsOH*H₂O / benzene / 1 h / Heating

3: 91 percent / pyridinium bromide perbromide / tetrahydrofuran / 0.25 h / Ambient temperature

4: 77 percent / t-BuOK / dimethylsulfoxide / 0.25 h / Ambient temperature

5: 1.) t-BuLi, 2.) HMPA / 1.) THF, pentane, 0 deg C, 1 h, 2.) THF, pentane, -78 deg C, 30 min

6: oxalic acid / CH₂Cl₂ / 2 h / Ambient temperature

7: (COCl)2, DMSO / CH₂Cl₂ / 0.5 h / -78 °C

8: ZnBr₂ / CH₂Cl₂ / 23 h / Ambient temperature

9: camphorsulfonic acid (CSA) / benzene / 18 h / Ambient temperature

10: 79 percent / dimethylsulfoxide; tetrahydrofuran / 1.75 h / 0 - 20 °C

11: 217 mg / H₂ / 10percent Pd/C / methanol / 0.75 h / Ambient temperature

12: NaIO₄, RuO₂ / H₂O; CCl₄; acetonitrile / 1.5 h / 0 - 20 °C

13: diethyl ether / 0 °C

15: 82 percent / NaBH₄ / methanol; tetrahydrofuran / 0.5 h / -20 °C

16: 4-(N,N-dimethylamino)pyridine (DMAP), unsym-N,N-dimethylethylenediamine / pyridine / 14.25 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; sodium dihydrogenphosphate; oxalyl dichloride; phosphoric acid; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; tert.-butyl lithium; pyridinium hydrobromide perbromide; oxalic acid; toluene-4-sulfonic acid; dimethyl sulfoxide; N,N-dimethylethylenediamine; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetonitrile; benzene;

Reference yield:

3,3-Dimethyl-1,5,9-trioxa-spiro[5.5]undecane (131067-46-4) → C26H31F3O8 (131103-12-3)

Guidance literature:

Multi-step reaction with 14 steps

1: 91 percent / pyridinium bromide perbromide / tetrahydrofuran / 0.25 h / Ambient temperature

2: 77 percent / t-BuOK / dimethylsulfoxide / 0.25 h / Ambient temperature

3: 1.) t-BuLi, 2.) HMPA / 1.) THF, pentane, 0 deg C, 1 h, 2.) THF, pentane, -78 deg C, 30 min

4: oxalic acid / CH₂Cl₂ / 2 h / Ambient temperature

5: (COCl)2, DMSO / CH₂Cl₂ / 0.5 h / -78 °C

6: ZnBr₂ / CH₂Cl₂ / 23 h / Ambient temperature

7: camphorsulfonic acid (CSA) / benzene / 18 h / Ambient temperature

8: 79 percent / dimethylsulfoxide; tetrahydrofuran / 1.75 h / 0 - 20 °C

9: 217 mg / H₂ / 10percent Pd/C / methanol / 0.75 h / Ambient temperature

10: NaIO₄, RuO₂ / H₂O; CCl₄; acetonitrile / 1.5 h / 0 - 20 °C

11: diethyl ether / 0 °C

13: 82 percent / NaBH₄ / methanol; tetrahydrofuran / 0.5 h / -20 °C

14: 4-(N,N-dimethylamino)pyridine (DMAP), unsym-N,N-dimethylethylenediamine / pyridine / 14.25 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; oxalyl dichloride; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; tert.-butyl lithium; pyridinium hydrobromide perbromide; oxalic acid; dimethyl sulfoxide; N,N-dimethylethylenediamine; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetonitrile; benzene;

upstream raw materials:

(R)-methoxytrifluoromethylphenylacetyl chloride

C₁₆H₂₂O₆

Tetrahydro-4H-pyran-4-one

1,5-dichloropentan-3-one

Refernces