1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:84230-24-0
Molecular Formula:C₂₅H₂₅NO₄
Molecular Weight:403.478
Hs Code.:

Synonyms:1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1-(3'-benzyloxy-5'-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 109-94-4
formic acid ethyl ester

: 84230-24-0
1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In N,N-dimethyl-formamide; for 14h; Heating;
DOI:10.1002/hlca.19820650531

Reference yield: 61.0%

: 77-78-1
dimethyl sulfate

: 84230-24-0
1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 84230-25-1
1-(3'-benzyloxy-5'-methoxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 85 - 90 ℃; for 16h;
DOI:10.1002/hlca.19820650531

Reference yield:

: 84230-24-0
1-(3'-benzyloxy-5'-hydroxybenzyl)-N-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 84230-28-4
1-(3'-hydroxy-5'-methoxybenzyl)-6-methoxy-1,2,3,4,5,8-hexahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / 59percent NaH / dimethylformamide / 16 h / 85 - 90 °C

2: 35 percent / 10percent HCl / methanol / 16 h / Heating

3: 78 percent / Li/NH₃(l) / 2-methyl-propan-2-ol; tetrahydrofuran / 0.5 h / -60 °C

With hydrogenchloride; ammonia; lithium; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/hlca.19820650531