(4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

Base Information

Chemical Name:(4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane
CAS No.:452085-14-2
Molecular Formula:C₄₇H₇₂O₅Si₂
Molecular Weight:773.257
Hs Code.:

(4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

Synonyms:(4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

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Chemical Property of (4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

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Technology Process of (4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

There total 19 articles about (4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025814-39-4
(4S,5R,6R)-6-(3-Benzyloxy-propyl)-2,2,5-trimethyl-[1,3]dioxane-4-carbaldehyde

: [(4R,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methyl-4-triethylsilanyloxy-hexyl]-triphenyl-phosphonium; iodide

: 452085-14-2
(4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

Guidance literature:: [(4R,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methyl-4-triethylsilanyloxy-hexyl]-triphenyl-phosphonium; iodide; With tert.-butyl lithium; In tetrahydrofuran; at -78 - -5 ℃;

(4S,5R,6R)-6-(3-Benzyloxy-propyl)-2,2,5-trimethyl-[1,3]dioxane-4-carbaldehyde; In tetrahydrofuran; at 10 ℃;
DOI:10.1016/S0040-4039(02)00655-X

Reference yield:

: 7-benzyloxy-3-methyl-hept-1-en-4-ol

: 452085-14-2
(4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 13 steps

1.1: DCC; DMAP / CH₂Cl₂ / 20 °C

2.1: OsO₄; NMO / acetone; H₂O / 20 °C

3.1: NaIO₄ / tetrahydrofuran; H₂O / 20 °C

4.1: NaBH₄ / tetrahydrofuran; H₂O / 0 °C

5.1: LiOH; H₂O / methanol / 20 °C

6.1: PPTS / toluene / Heating

7.1: Li; liq. NH₃ / tetrahydrofuran / -78 °C

8.1: Ph₃P; I₂; imidazole / tetrahydrofuran / 0 °C

9.1: cc. HCl / methanol / 0 °C

10.1: DMAP; Et₃N / CH₂Cl₂ / -15 °C

11.1: DMAP; Et₃N / CH₂Cl₂ / -15 °C

12.1: K₂CO₃ / acetonitrile / Heating

13.1: t-BuLi / tetrahydrofuran / -78 - -5 °C

13.2: tetrahydrofuran / 10 °C

With 1H-imidazole; hydrogenchloride; dmap; lithium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; ammonia; water; iodine; tert.-butyl lithium; pyridinium p-toluenesulfonate; lithium; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; acetonitrile; 13.2: Wittig olefination;
DOI:10.1016/S0040-4039(02)00655-X

Reference yield:

: (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[4-benzyloxy-1-(1-methyl-2-oxo-ethyl)-butyl] ester

: 452085-14-2
(4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaBH₄ / tetrahydrofuran; H₂O / 0 °C

2.1: LiOH; H₂O / methanol / 20 °C

3.1: PPTS / toluene / Heating

4.1: Li; liq. NH₃ / tetrahydrofuran / -78 °C

5.1: Ph₃P; I₂; imidazole / tetrahydrofuran / 0 °C

6.1: cc. HCl / methanol / 0 °C

7.1: DMAP; Et₃N / CH₂Cl₂ / -15 °C

8.1: DMAP; Et₃N / CH₂Cl₂ / -15 °C

9.1: K₂CO₃ / acetonitrile / Heating

10.1: t-BuLi / tetrahydrofuran / -78 - -5 °C

10.2: tetrahydrofuran / 10 °C

With 1H-imidazole; hydrogenchloride; dmap; lithium hydroxide; sodium tetrahydroborate; ammonia; water; iodine; tert.-butyl lithium; pyridinium p-toluenesulfonate; lithium; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile; 10.2: Wittig olefination;
DOI:10.1016/S0040-4039(02)00655-X