(4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

Base Information

Chemical Name:(4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one
CAS No.:210635-16-8
Molecular Formula:C₅₂H₇₀N₆O₅Si₂
Molecular Weight:915.336
Hs Code.:

(4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

Synonyms:(4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

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Chemical Property of (4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

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Technology Process of (4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

There total 8 articles about (4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 187274-94-8
5-(bromomethyl)-1-SEM-indazole

: 210635-15-7
(4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

: 210635-16-8
(4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1021/jm9803626

Reference yield:

: 179894-02-1
Acetic acid (4R,5S,6S,7R)-4,7-dibenzyl-6-hydroxy-2-oxo-[1,3]diazepan-5-yl ester

: 210635-16-8
(4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.9 g / DAST / CH₂Cl₂ / 0.5 h / 0 °C

2: 900 mg / HBr gas / dioxane / 0.33 h / Ambient temperature

3: KOH / methanol / Ambient temperature

4: 6.3 g / H₂ / 10 percent Pd/C / tetrahydrofuran; methanol / 3 h / 2585.74 Torr / Ambient temperature

5: 7.8 g / TsOH*H₂O / CHCl₃ / Ambient temperature

6: 75 percent / t-BuOK / tetrahydrofuran / 0.5 h / Ambient temperature

With potassium hydroxide; potassium tert-butylate; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform;
DOI:10.1021/jm9803626

Reference yield:

: 188978-55-4
(4R,5S,6R,7R)-1,3-diaza-4,7-bis-(phenylmethyl)-5-(acetyloxy)-bicyclo<4.1.0>heptan-2-one

: 210635-16-8
(4R,5R,6R)-4-Benzyl-6-phenethyl-5-(tetrahydro-pyran-2-yloxy)-1,3-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-tetrahydro-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 900 mg / HBr gas / dioxane / 0.33 h / Ambient temperature

2: KOH / methanol / Ambient temperature

3: 6.3 g / H₂ / 10 percent Pd/C / tetrahydrofuran; methanol / 3 h / 2585.74 Torr / Ambient temperature

4: 7.8 g / TsOH*H₂O / CHCl₃ / Ambient temperature

5: 75 percent / t-BuOK / tetrahydrofuran / 0.5 h / Ambient temperature

With potassium hydroxide; potassium tert-butylate; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform;
DOI:10.1021/jm9803626