(4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

Base Information

Chemical Name:(4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone
CAS No.:210635-15-7
Molecular Formula:C₂₄H₃₀N₂O₃
Molecular Weight:394.514
Hs Code.:

Synonyms:(4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

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Chemical Property of (4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

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Technology Process of (4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

There total 6 articles about (4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179894-02-1
Acetic acid (4R,5S,6S,7R)-4,7-dibenzyl-6-hydroxy-2-oxo-[1,3]diazepan-5-yl ester

: 210635-15-7
(4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.9 g / DAST / CH₂Cl₂ / 0.5 h / 0 °C

2: 900 mg / HBr gas / dioxane / 0.33 h / Ambient temperature

3: KOH / methanol / Ambient temperature

4: 6.3 g / H₂ / 10 percent Pd/C / tetrahydrofuran; methanol / 3 h / 2585.74 Torr / Ambient temperature

5: 7.8 g / TsOH*H₂O / CHCl₃ / Ambient temperature

With potassium hydroxide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform;
DOI:10.1021/jm9803626

Reference yield:

: 210635-12-4
(4S,5S,6R)-tetrahydro-5-(acetyloxy)-4-(1S-bromo-2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

: 210635-15-7
(4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / methanol / Ambient temperature

2: 6.3 g / H₂ / 10 percent Pd/C / tetrahydrofuran; methanol / 3 h / 2585.74 Torr / Ambient temperature

3: 7.8 g / TsOH*H₂O / CHCl₃ / Ambient temperature

With potassium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm9803626

Reference yield:

: 188978-55-4
(4R,5S,6R,7R)-1,3-diaza-4,7-bis-(phenylmethyl)-5-(acetyloxy)-bicyclo<4.1.0>heptan-2-one

: 210635-15-7
(4R,5R,6R)-tetrahydro-5-(tetrahydropyran-2-yl-oxy)-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 900 mg / HBr gas / dioxane / 0.33 h / Ambient temperature

2: KOH / methanol / Ambient temperature

3: 6.3 g / H₂ / 10 percent Pd/C / tetrahydrofuran; methanol / 3 h / 2585.74 Torr / Ambient temperature

4: 7.8 g / TsOH*H₂O / CHCl₃ / Ambient temperature

With potassium hydroxide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform;
DOI:10.1021/jm9803626