methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Base Information

Chemical Name:methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate
CAS No.:136564-72-2
Molecular Formula:C₂₇H₂₅NO₅
Molecular Weight:443.499
Hs Code.:

Synonyms:methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

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Chemical Property of methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

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Technology Process of methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

There total 4 articles about methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136564-71-1
methyl 4-<<5-(benzyloxycarbonyl)indol-3-yl>methyl>-3-methoxybenzoate

: 74-88-4
methyl iodide

: 136564-72-2
methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 1 h, 2.) DMF, from 0 deg C to RT, 1 h;
DOI:10.1021/jm00055a011

Reference yield:

: 1670-81-1,142396-03-0
1H-Indole-5-carboxylic acid

: 136564-72-2
methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / triphenylphosphine, diethylazodicarboxylate / tetrahydrofuran / 24 h / Ambient temperature

2: 32 percent / dimethylformamide / 24 h / 80 °C

3: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, from 0 deg C to RT, 1 h

With sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00055a011

Reference yield:

: 136564-69-7
1H-indole-5-carboxylic acid benzyl ester

: 136564-72-2
methyl 4-<<5-(benzyloxycarbonyl)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / dimethylformamide / 24 h / 80 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, from 0 deg C to RT, 1 h

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00055a011