diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate

Base Information

Chemical Name:diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate
CAS No.:1436463-10-3
Molecular Formula:C₁₈H₂₁NO₆
Molecular Weight:347.368
Hs Code.:

Synonyms:diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate

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Chemical Property of diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate

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Technology Process of diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate

There total 6 articles about diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1436463-05-6
1-tert-butyl 2,2-diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-1,2,2-tricarboxylate

: 1436463-10-3
diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2013.03.130

Reference yield:

: 1132641-34-9
methyl 2-(((tert-butoxycarbonyl)oxy)(4-methoxyphenyl)methyl)acrylate

: 102831-44-7
diethyl tert-butoxycarbonylaminomalonate

: 1436463-10-3
diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate

Guidance literature:: methyl 2-{[(tertbutoxycarbonyl)oxy](4-methoxyphenyl)methyl}acrylate; diethyl tert-butoxycarbonylaminomalonate; With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; at 20 ℃;

With trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1016/j.tet.2013.11.028

Reference yield:

: (3SR,4RS)-diethyl 4-(diethoxyphosphoryl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2,2-dicarboxylate

: 1436463-10-3
diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 3 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 1 h

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dmap; potassium tert-butylate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tetlet.2013.03.130