(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Base Information

Chemical Name:(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride
CAS No.:1541199-32-9
Molecular Formula:C₁₄H₁₇ClF₃NO₃*ClH
Molecular Weight:376.203
Hs Code.:

Synonyms:(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

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Chemical Property of (S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

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Technology Process of (S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

There total 7 articles about (S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1541199-33-0
(3S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoic acid

: 1541199-32-9
(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: With hydrogenchloride; Reflux; Inert atmosphere;

Reference yield:

: 1541198-33-7
C₁₂H₁₂ClF₃O₃

: 1541199-32-9
(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / acetone / 5 h / 20 °C / Inert atmosphere

2.1: ammonium acetate / ethanol / 7 h / Inert atmosphere

3.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.34 / Enzymatic reaction

3.2: 20 °C

4.1: hydrogenchloride / Reflux; Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; toluene-4-sulfonic acid; sodium hydroxide; In ethanol; water; acetone;

Reference yield:

: 1541198-34-8
C₁₀H₈ClF₃O₂

: 1541199-32-9
(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / ethanol / 7 h / Inert atmosphere

2.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.34 / Enzymatic reaction

2.2: 20 °C

3.1: hydrogenchloride / Reflux; Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; sodium hydroxide; In ethanol; water;