(R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

Base Information

Chemical Name:(R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate
CAS No.:1607830-33-0
Molecular Formula:C₁₈H₂₈O₅Si
Molecular Weight:352.503
Hs Code.:

Synonyms:(R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

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Technology Process of (R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

There total 7 articles about (R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 91424-40-7
3-(tert-butyldimethylsilyloxy)glutaric anhydride

: 100-51-6,185532-71-2
benzyl alcohol

: 1607830-33-0
(R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

Guidance literature:: With C₂₇H₃₁N₃O₃S; In tert-butyl methyl ether; enantioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201301374

Reference yield: 67.0%

: 91424-40-7
3-(tert-butyldimethylsilyloxy)glutaric anhydride

: 100-51-6,185532-71-2
benzyl alcohol

: (S)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

: 1607830-33-0
(R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

Guidance literature:: With xanthene-9-carboxylic acid; quinindine; In tert-butyl methyl ether; for 72h; Reagent/catalyst; Time; Temperature; enantioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201301374

Reference yield:

: 32328-03-3
diethyl 3-hydroxyglutarate

: 1607830-33-0
(R)-monobenzyl 3-(tert-butyldimethylsilyloxy)glutarate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / dichloromethane

2: potassium hydroxide; water

3: acetic anhydride / 100 °C

4: C₂₇H₃₁N₃O₃S / tert-butyl methyl ether / 48 h

With 1H-imidazole; C₂₇H₃₁N₃O₃S; water; acetic anhydride; potassium hydroxide; In dichloromethane; tert-butyl methyl ether;
DOI:10.1002/ejoc.201301374