2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid

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Chemical Name:2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid
CAS No.:1312949-18-0
Molecular Formula:C₁₆H₁₃F₃N₄O₂
Molecular Weight:350.3
Hs Code.:

Synonyms:2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid

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Chemical Property of 2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid

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Technology Process of 2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid

There total 4 articles about 2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 614-16-4
Benzoylacetonitrile

: 1312949-18-0
2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 1.5 h / 110 °C / microwave irradiation

2.1: acetic acid / 10 h / 150 °C

3.1: phosphorus(V) oxybromide / 3 h / 120 °C

4.1: sodium carbonate / N,N-dimethyl-formamide / 6 h / 20 - 100 °C

5.1: water; lithium hydroxide monohydrate / ethanol / 0.25 h / 20 °C

5.2: pH 2

With lithium hydroxide monohydrate; water; sodium carbonate; acetic acid; phosphorus(V) oxybromide; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 10199-50-5
1-methyl-3-phenyl-1H-pyrazol-5-amine

: 1312949-18-0
2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 10 h / 150 °C

2.1: phosphorus(V) oxybromide / 3 h / 120 °C

3.1: sodium carbonate / N,N-dimethyl-formamide / 6 h / 20 - 100 °C

4.1: water; lithium hydroxide monohydrate / ethanol / 0.25 h / 20 °C

4.2: pH 2

With lithium hydroxide monohydrate; water; sodium carbonate; acetic acid; phosphorus(V) oxybromide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1312949-15-7
1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

: 1312949-18-0
2-(1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ylamino)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus(V) oxybromide / 3 h / 120 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 6 h / 20 - 100 °C

3.1: water; lithium hydroxide monohydrate / ethanol / 0.25 h / 20 °C

3.2: pH 2

With lithium hydroxide monohydrate; water; sodium carbonate; phosphorus(V) oxybromide; In ethanol; N,N-dimethyl-formamide;