10199-50-5

Basic information

• Product Name: 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE
• Synonyms: VITAS-BB TBB000664;TIMTEC-BB SBB005507;1-METHYL-3-PHENYL-1H-PYRAZOL-5-AMINE;5-AMINO-1-METHYL-3-PHENYLPYRAZOLE;BUTTPARK 30\09-85;1-methyl-3-phenyl-5-pyrazolamine;5-Amino-1-methyl-3-phenyl-1H-pyrazole;5-Amino-1-menthyl-3-phenylpyrazole
• CAS NO: 10199-50-5
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21
• EINECS: -0
• Mol File: 10199-50-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 125-128°C
• Boiling Point: 368.1 °C at 760 mmHg
• Flash Point: 176.4 °C
• Appearance: cream crystals
• Density: 1.17 g/cm³
• Vapor Pressure: 1.3E-05mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 3?+-.0.10(Predicted)
• BRN: 743807
• CAS DataBase Reference: 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE(10199-50-5)
• EPA Substance Registry System: 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE(10199-50-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 10199-50-5(Hazardous Substances Data)

Usage

Uses

1-Methyl-3-phenyl-1H-pyrazol-5-amine can be used to selectively target the TPX2 Site of Importin-?α Using Fragment-?Based Ligand Design.

InChI:InChI=1/C10H11N3/c1-13-10(11)7-9(12-13)8-5-3-2-4-6-8/h2-7H,11H2,1H3

Upstream product

• 1537216-91-3 5-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-3-phenyl-1H-pyrazole 
• 93-89-0 benzoic acid ethyl ester 
• 7339-53-9 methyl hydrazine hydrochloride 
• 614-16-4 Benzoylacetonitrile 
• 22038-72-8 methyldiazene 
• 624-80-6 ethylhydrazine 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 54962-76-4 5-azido-1-methyl-3-phenyl-1H-pyrazole 
• 1402242-56-1 potassium trifluoro(3-hydroxy-3-phenylprop-1-yn-1-yl)borate 
• 1402242-69-6 potassium trifluoro(1-methyl-3-phenyl-1H-pyrazol-5-yl)borate 
• 1402242-62-9 potassium trifluoro(3-oxo-3-phenylprop-1-yn-1-yl)borate 
• 93-58-3 benzoic acid methyl ester 
• 60-34-4 methylhydrazine 
• 98-86-2 acetophenone 

Downstream Products

• 91623-40-4 4-cyclohex-1-enyl-2-methyl-5-phenyl-2H-pyrazol-3-ylamine 
• 132026-42-7 4,5-diamino-1-methyl-3-phenyl-1H-pyrazole 
• 88-06-2 2,4,6-Trichlorophenol 
• 19848-97-6 5-Amino-1-methyl-4-nitroso-3-phenylpyrazole 

Relevant articles and documents

Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence, and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen's hu

Difluoromethylthiolation of Phenols and Related Compounds with a HF2CSO2Na/Ph2PCl/Me3SiCl System

A novel HF2CSO2Na/Ph2PCl/Me3SiCl system is disclosed for the late-stage direct difluoromethylthiolation of Csp2 and Csp3 nucleophiles. Difluoromethylthiolation of phenols and naphthols proceeded nicely under this system to regioselectively provide corresponding SCF2H compounds in good yields. Other substrates such as indoles, pyrroles, pyrazoles, enamines, ketones, and β-keto esters were also transformed to corresponding SCF2H products in good yields. The late-stage direct difluoromethylthiolation of a number of natural products and pharmaceutically attractive molecules was also achieved.

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)

Compound rac-1 was identified by high throughput screening. Here we report SAR studies and MedChem optimization towards the highly potent dual orexin receptor antagonists (S)-2 and (S)-3. Furthermore, strategies to overcome the suboptimal physicochemical properties are highlighted and the pharmacokinetic profiles of representative compounds is presented.