N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine

Base Information

• Chemical Name: N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine
• CAS No.: 160193-59-9
• Molecular Formula: C₂₃H₂₆N₂O₂
• Molecular Weight: 362.472
• Mol file: 160193-59-9.mol

Synonyms:N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine

Chemical Property of N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine

There total 2 articles about N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-phenoxybenzyl chloride (53874-66-1) + (1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropanacetamide O-tosyloxime (160193-58-8) → N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine (160193-59-9)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; In potassium hydroxide; dichloromethane; for 2h; Heating;

DOI:10.1055/s-1994-25608

Reference yield:

(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropanacetamide oxime (125558-05-6) → N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine (160193-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / pyridine / CH₂Cl₂ / 2 h / -10 °C

2: 80 percent / benzyltriethylammonium chloride / CH₂Cl₂; aq. KOH / 2 h / Heating

With pyridine; N-benzyl-N,N,N-triethylammonium chloride; In potassium hydroxide; dichloromethane;

DOI:10.1055/s-1994-25608

Reference yield: 85.0%

methyl magnesium iodide (917-64-6) + N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropylmethyl>amine (160193-59-9) → N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-hydroxy-2-methylpropyl)cyclopropylmethyl>amine (160193-60-2)

Guidance literature:

In diethyl ether; for 2h; Heating;

DOI:10.1055/s-1994-25608

upstream raw materials:

3-phenoxybenzyl chloride

(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropanacetamide O-tosyloxime

(1R,3S)-2,2-dimethyl-3-(2-oxopropyl)cyclopropanacetamide oxime

Downstream raw materials:

N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-hydroxy-2-methylpropyl)cyclopropylmethyl>amine

N-cyano-N-(m-phenoxybenzyl)<(1R,3S)-2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropylmethyl>amine