7-HYDROXY-6-PHENYL-2,3-DIHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-5-ONE

Base Information

• Chemical Name: 7-HYDROXY-6-PHENYL-2,3-DIHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-5-ONE
• CAS No.: 57625-49-7
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.323
• Mol file: 57625-49-7.mol

Synonyms:4-hydroxy-3-phenyl-1-azatricyclo[7.3.1.0^5,13]trideca-3,5,7,9⁽¹³⁾-tetraen-2-one

Chemical Property of 7-HYDROXY-6-PHENYL-2,3-DIHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-5-ONE

Chemical Property:

• Vapor Pressure: 1.58E-09mmHg at 25°C
• Melting Point: 220 °C(Solv: ethanol (64-17-5))
• Boiling Point: 460.1±45.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-HYDROXY-6-PHENYL-2,3-DIHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-5-ONE

There total 1 articles about 7-HYDROXY-6-PHENYL-2,3-DIHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-5-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + diethyl 2-phenylmalonate (83-13-6) → 4-hydroxy-3-phenyl-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one (57625-49-7)

Guidance literature:

1) 220 deg C - 250 deg C, 1 h, 2) 300 deg C;

DOI:10.1007/BF00909657

Reference yield: 87.0%

4-hydroxy-3-phenyl-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one (57625-49-7) → 1-Chlor-2-phenyl-6,7-dihydro-3H,5H-benzochinolizin-3-on (57625-54-4)

Guidance literature:

With trichlorophosphate; for 2h; Heating;

DOI:10.1007/BF00809016

Reference yield: 83.0%

4-hydroxy-3-phenyl-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one (57625-49-7) + benzenesulfonyl chloride (98-09-9) → 2-phenyl-1-phenylsulfonyloxy-5,6-dihydro-3a-azaphenalen-3(4H)-one (137786-78-8)

Guidance literature:

With pyridine; for 1h; Ambient temperature;

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

diethyl 2-phenylmalonate

Downstream raw materials:

1-Chlor-2-phenyl-6,7-dihydro-3H,5H-benzochinolizin-3-on

2-Hydroxy-2-phenyl-2,3,6,7-tetrahydro-1H,5H-benzochinolizin-1,3-dion

2-phenyl-1-phenylsulfonyloxy-5,6-dihydro-3a-azaphenalen-3(4H)-one

2-Phenyl-1-tosyloxy-6,7-dihydro-5H-benzochinolizin-3-on