[3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

Base Information

Chemical Name:[3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone
CAS No.:199604-67-6
Molecular Formula:C₂₇H₅₂O₃Si₂
Molecular Weight:480.879
Hs Code.:

Synonyms:[3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

Chemical Property:

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Technology Process of [3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

There total 2 articles about [3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 263381-45-9
[3R(1E,3R),4R]-3-(3-cyclohexyl-3-hydroxypropyl)-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

: 199604-67-6
[3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

Reference yield:

: 199604-67-6
[3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

Guidance literature:

Reference yield: 72.0%

: 263381-41-5
Z-3-(tri-n-butylstannyl)-2-propen-1-yl (1'-ethoxy)ethyl ether

: 199604-67-6
[3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone

: (2R,3R,4R)-2-[1'-[(2'Z)-4'-[(1-ethoxy)ethoxy]-2'-butenyl]]-3-[1'-[(3'R)-3'-(t-butyldimethylsiloxy)-3'-cyclohexyl]-propyl]-4-(t-butyldimethylsiloxy)-cyclopentan-1-one

Guidance literature:: Z-3-(tri-n-butylstannyl)-2-propen-1-yl (1'-ethoxy)ethyl ether; With methyllithium; copper(I) cyanide; In tetrahydrofuran; iso-propylbenzene; at 0 - 20 ℃; for 1.58333h;

[3R(1E,3R),4R]-3-[3-cyclohexyl-3-(t-butyldimethylsiloxy)propyl]-4-(t-butyldimethylsiloxy)-2-methylenecyclopentanone; In tetrahydrofuran; iso-propyl benzene; at -78 ℃; for 0.166667h;

With ammonium chloride; In tetrahydrofuran; iso-propyl benzene; water;