263381-45-9Relevant academic research and scientific papers
Stannane synthesis of prostanoids
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Page column 10, (2010/02/05)
The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane intermediates.
3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.
Hellberg, Mark R,Conrow, Raymond E,Sharif, Najam A,McLaughlin, Marsha A,Bishop, John E,Crider, Julie Y,Dean, W Dennis,DeWolf, Kevin A,Pierce, David R,Sallee, Verney L,Selliah, Robert D,Severns, Bryon S,Sproull, Steven J,Williams, Gary W,Zinke, Paul W,Klimko, Peter G
, p. 2031 - 2049 (2010/12/01)
A series of prostaglandin DP agonists containing a 3-oxa-15-cyclohexyl motif was synthesized and evaluated in several in vitro and in vivo biological assays. The reference compound ZK 118.182 (9beta-chloro-15-cyclohexyl-3-oxa-omega-pentanor PGF(2alpha)) i
