5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine

Base Information

Chemical Name:5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine
CAS No.:1234015-63-4
Molecular Formula:C₂₂H₂₀BrN₅O₃
Molecular Weight:482.336
Hs Code.:

Synonyms:5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine

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Chemical Property of 5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine

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Technology Process of 5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine

There total 1 articles about 5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 59489-71-3
5-amino-2-bromopyrazine

: 1234015-62-3
1-(2-methoxy-6-((4-methoxyphenyl)methoxy)phenyl)-3,3-bis(methylsulfonyl)-2-propen-1-one

: 1234015-63-4
5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine

Guidance literature:: 5-amino-2-bromopyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

1-(2-methoxy-6-((4-methoxyphenyl)methoxy)phenyl)-3,3-bis(methylsulfonyl)-2-propen-1-one; In tetrahydrofuran; hexane; at 0 ℃; Reflux;

With hydrazine hydrate; In ethanol; acetic acid; Reflux;

Reference yield: 64.0%

: 1234015-63-4
5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine

: 1234015-64-5
2-(3-(5-bromopyrazin-2-ylamino)-1H-pyrazol-5-yl)-3-methoxyphenol

Guidance literature:: 5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine; With hydrogenchloride; In methanol;

With sodium hydrogencarbonate; In chloroform; water; isopropyl alcohol;

Reference yield:

: 1234015-63-4
5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine

: 1234015-52-1
5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / methanol / 2.33 h

2: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

4: hydrogenchloride / ethyl acetate / 5.25 h / 10 °C / Cooling with ice

5: sodium hydroxide / dichloromethane; water / 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;