2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one

Base Information

Chemical Name:2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one
CAS No.:944331-35-5
Molecular Formula:C₂₉H₄₃F₂N₃O₅Si₂
Molecular Weight:607.845
Hs Code.:

Synonyms:2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one

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Chemical Property of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one

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Technology Process of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one

There total 12 articles about 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 944331-26-4
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 944331-36-6
2-bromo-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

: 944331-35-5
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one

Guidance literature:: With potassium phosphate; palladium diacetate; catacxium A; In water; toluene; for 6h; Heating / reflux;

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 944331-35-5
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C

2: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 3 h / 20 °C

3: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C

4: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C

5: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

7: potassium phosphate / palladium diacetate; catacxium A / water; toluene / 6 h / Heating / reflux

With sodium hydroxide; potassium phosphate; dimethyl zinc(II); potassium acetate; boron tribromide; potassium carbonate; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; catacxium A; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 7: Suzuki Coupling;

Reference yield:

: 485402-61-7
4-bromo-(2-cyclopropyloxy)phenol

: 944331-35-5
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

3: potassium phosphate / palladium diacetate; catacxium A / water; toluene / 6 h / Heating / reflux

With sodium hydroxide; potassium phosphate; potassium acetate; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; catacxium A; In 1,4-dioxane; water; toluene; 3: Suzuki Coupling;