2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Base Information

Chemical Name:2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
CAS No.:944331-26-4
Molecular Formula:C₁₆H₂₁BF₂O₄
Molecular Weight:326.148
Hs Code.:

Synonyms:2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

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Chemical Property of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

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Technology Process of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

There total 6 articles about 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 944333-93-1
4-bromo-2-cyclopropoxy-1-difluoromethoxybenzene

: 73183-34-3
bis(pinacol)diborane

: 944331-26-4
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 80 ℃; for 12h;

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 944331-26-4
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C

2: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 3 h / 20 °C

3: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C

4: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C

5: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

With sodium hydroxide; dimethyl zinc(II); potassium acetate; boron tribromide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 944334-01-4
4-bromo-2-vinyloxy-1-methoxybenzene

: 944331-26-4
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C

2: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C

3: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

With sodium hydroxide; dimethyl zinc(II); potassium acetate; boron tribromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; In 1,4-dioxane; dichloromethane; water; toluene;