(1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane

Base Information

• Chemical Name: (1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane
• CAS No.: 118710-95-5
• Molecular Formula: C₁₉H₂₆O₄
• Molecular Weight: 318.413
• Mol file: 118710-95-5.mol

Synonyms:(1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane

Chemical Property of (1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane

There total 6 articles about (1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-2-methylcyclohexanol (118598-76-8) + benzoyl chloride (98-88-4) → (1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane (118710-95-5)

Guidance literature:

With pyridine; at 0 ℃; for 12h;

DOI:10.1021/jo00268a012

Reference yield:

(2R,4R)-(+)-2-methyl-4-(2-acetoxy-2-methylethyl)cyclohexanone (118710-93-3) → (1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-1-(benzoyloxy)-2-methylcyclohexane (118710-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / 0 °C

2: 91 percent / pyridine / 12 h / 0 °C

With pyridine; lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran;

DOI:10.1021/jo00268a012

Reference yield:

(2R,4R)-(+)-2-methyl-4-(2-acetoxy-2-methylethyl)cyclohexanone (118710-93-3) → Benzoic acid (1R,2S,4S)-4-(1-acetoxy-1-methyl-ethyl)-2-methyl-cyclohexyl ester (118598-72-4,118710-95-5,118710-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / 0 °C

2: pyridine / 12 h / 0 °C

With pyridine; lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran;

DOI:10.1021/jo00268a012

upstream raw materials:

(1R,2R,4R)-4-(2-acetoxy-2-methylethyl)-2-methylcyclohexanol

benzoyl chloride

(2R,4R)-(+)-2-methyl-4-(2-acetoxy-2-methylethyl)cyclohexanone

(4R,6R)-(+)-1-acetoxy-4-(2-acetoxy-2-methylethyl)-6-methyl-1-cyclohexene