1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

Base Information

• Chemical Name: 1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one
• CAS No.: 145659-80-9
• Molecular Formula: C₂₅H₂₁N₇O₃
• Molecular Weight: 467.487

Synonyms:1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

Chemical Property of 1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

Chemical Property:

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Technology Process of 1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

There total 2 articles about 1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dihydro-1-cyanomethyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one (145659-79-6) → 1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one (145659-80-9)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 110 ℃; for 4h;

DOI:10.1021/jm00078a018

Reference yield:

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate (108895-98-3) → 1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one (145659-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF

2: NaN₃, NH₄Cl / dimethylformamide / 4 h / 110 °C

With sodium azide; sodium hydride; ammonium chloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00078a018

Reference yield:

1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one (145659-80-9) → 1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-amino-5-phenyl-2H-1,4-benzodiazepin-2-one hydrobromide

Guidance literature:

With hydrogen bromide; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm00078a018

upstream raw materials:

1,3-dihydro-1-cyanomethyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

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