N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

Base Information

Chemical Name:N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide
CAS No.:1380919-34-5
Molecular Formula:C₃₁H₃₀Cl₂F₃N₅O
Molecular Weight:616.513
Hs Code.:

Synonyms:N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

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Chemical Property of N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

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Technology Process of N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

There total 3 articles about N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1242269-29-9
N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide

: 1380921-58-3
5-chloro-2-methylamino-4-(4-phenyl-piperidin-1-yl)aniline

: 1380919-34-5
N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

Guidance literature:: N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide; 5-chloro-2-methylamino-4-(4-phenyl-piperidin-1-yl)aniline; In N,N-dimethyl-formamide; at 20 ℃;

With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 90 ℃; for 1.5h;

Reference yield:

: 1242269-27-7
N-(4-chloro-3-nitro-benzyl)-1-trifluoromethyl-cyclopropane carboxamide

: 1380919-34-5
N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / Raney-Nickle / ethyl acetate / 20 °C / 2250.23 Torr

2.1: diisopropyl-carbodiimide / dichloromethane / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

3.2: 1.5 h / 90 °C

With hydrogen; diisopropyl-carbodiimide; Raney-Nickle; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1242269-28-8
N-(4-chloro-3-amino-benzyl)-1-trifluoromethyl-cyclopropane carboxamide

: 1380919-34-5
N-{4-chloro-3-[5-chloro-1-methyl-6-(4-phenyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N-dimethyl-formamide / 20 °C

2.2: 1.5 h / 90 °C

With diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;