2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid ethyl ester

Base Information

Chemical Name:2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid ethyl ester
CAS No.:144060-92-4
Molecular Formula:C17H22 N2 O3 S
Molecular Weight:334.43
Hs Code.:
DSSTox Substance ID:DTXSID40601535
Nikkaji Number:J3.610.254C
Wikidata:Q72439376
Mol file:144060-92-4.mol

Synonyms:144060-92-4;2-[3-AMINO-4-(2-METHYLPROPOXY)PHENYL]-4-METHYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER;ethyl 2-[3-amino-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate;2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid ethylester;RQDZYELGFUZPQX-UHFFFAOYSA-N;SCHEMBL469542;DTXSID40601535;AKOS015900020;AC-9023;Ethyl 2-(3-amino-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylate

Suppliers and Price of 2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid ethylester
500 mg
$ 305.00

Biosynth Carbosynth
2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid ethylester
250 mg
$ 175.00

Biosynth Carbosynth
2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid ethylester
100 mg
$ 88.00

Biosynth Carbosynth
2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid ethylester
50 mg
$ 51.00

Biosynth Carbosynth
2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid ethylester
1 g
$ 528.00

AK Scientific
2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacidethylester
500mg
$ 461.00

Total 8 raw suppliers

Chemical Property of 2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid ethyl ester

Chemical Property:

Vapor Pressure:1.11E-09mmHg at 25°C
Refractive Index:1.57
Boiling Point:488.2 °C at 760 mmHg
Flash Point:249 °C
PSA：102.68000
Density:1.176g/cm³
LogP:4.49340
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:334.13511374
Heavy Atom Count:23
Complexity:394

Purity/Quality:

98% ^*data from raw suppliers

2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid ethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(S1)C2=CC(=C(C=C2)OCC(C)C)N)C

Technology Process of 2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid ethyl ester

There total 3 articles about 2-[3-Amino-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144060-93-5
ethyl 4-methyl-2-[3-nitro-4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate

: 144060-92-4
ethyl 2-[3-amino-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 50 ℃; for 14h;

Reference yield:

: 876938-69-1
4-bromo-1-(2-methylpropoxy)-2-nitrobenzene

: 144060-92-4
ethyl 2-[3-amino-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium dichloride; isobutyric Acid; di-tert-butyl(cyclohexyl)phosphine; potassium hydrogencarbonate; copper(I) bromide / toluene / 14 h / 120 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 14 h / 50 °C

With di-tert-butyl(cyclohexyl)phosphine; palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; isobutyric Acid; copper(I) bromide; palladium dichloride; In ethanol; toluene;

Reference yield:

: 7693-52-9
4-bromo-2-nitrophenol

: 144060-92-4
ethyl 2-[3-amino-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 22 h / 110 °C / Inert atmosphere

2: palladium dichloride; isobutyric Acid; di-tert-butyl(cyclohexyl)phosphine; potassium hydrogencarbonate; copper(I) bromide / toluene / 14 h / 120 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 14 h / 50 °C

With di-tert-butyl(cyclohexyl)phosphine; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydrogencarbonate; isobutyric Acid; copper(I) bromide; palladium dichloride; In ethanol; N,N-dimethyl-formamide; toluene;