N⁶-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Base Information

• Chemical Name: N⁶-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine
• CAS No.: 183281-91-6
• Molecular Formula: C₄₃H₃₇N₅O₁₂
• Molecular Weight: 815.793

Synonyms:N⁶-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Chemical Property of N⁶-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Chemical Property:

Purity/Quality:

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Technology Process of N⁶-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

There total 3 articles about N⁶-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N6-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (169687-74-5) → N6-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (183281-91-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1080/07328309708006511

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) → N6-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (183281-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin tetrachloride / 1,2-dichloro-ethane / 0.17 h / 0 °C

1.2: 77 percent / 1,2-dichloro-ethane / 7 h / 0 °C

2.1: 91 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.25 h / 20 °C

With tetrabutyl ammonium fluoride; tin(IV) chloride; In tetrahydrofuran; 1,2-dichloro-ethane; 1.1: stannylation / 1.2: glycosylation / 2.1: desilylation;

DOI:10.1080/07328309708006511

Reference yield:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N6-benzoyladenosine (79154-57-7) → N6-benzoyl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (183281-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin tetrachloride / 1,2-dichloro-ethane / 0.17 h / 0 °C

1.2: 77 percent / 1,2-dichloro-ethane / 7 h / 0 °C

2.1: 91 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.25 h / 20 °C

With tetrabutyl ammonium fluoride; tin(IV) chloride; In tetrahydrofuran; 1,2-dichloro-ethane; 1.1: stannylation / 1.2: glycosylation / 2.1: desilylation;

DOI:10.1080/07328309708006511

upstream raw materials:

N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

Downstream raw materials:

2'-O-β-D-ribofuranosyladenine

C₇₃H₇₂N₇O₁₅P

C₆₄H₅₅N₅O₁₄

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