(S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide

Base Information

Chemical Name:(S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide
CAS No.:135430-55-6
Molecular Formula:C₂₀H₂₄N₄O₂S
Molecular Weight:384.502
Hs Code.:

Synonyms:(S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide

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Technology Process of (S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide

There total 7 articles about (S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.5%

: 135430-32-9
(S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazol-2-ylsulfanyl)-phenyl]-amide

: 135430-55-6
(S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In methanol; chloroform; at -5 ℃; for 0.5h;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 2018-66-8
Z-Leu-OH

: 135430-55-6
(S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / hexamethylphosphoric acid triamide; acetonitrile / 0.25 h / -5 - 0 °C

2: hexamethylphosphoric acid triamide; acetonitrile / 4 h / Ambient temperature

3: 94.7 percent / 30percent HBr-AcOH / 2 h / Ambient temperature

4: 77.5 percent / m-chloroperbenzoic acid / CHCl₃; methanol / 0.5 h / -5 °C

With thionyl chloride; hydrogen bromide; acetic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; chloroform; acetonitrile;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 87052-59-3
N-Z-Leucine chloride

: 135430-55-6
(S)-2-Amino-4-methyl-pentanoic acid [2-(5-methyl-1H-benzoimidazole-2-sulfinyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: hexamethylphosphoric acid triamide; acetonitrile / 4 h / Ambient temperature

2: 94.7 percent / 30percent HBr-AcOH / 2 h / Ambient temperature

3: 77.5 percent / m-chloroperbenzoic acid / CHCl₃; methanol / 0.5 h / -5 °C

With hydrogen bromide; acetic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; chloroform; acetonitrile;
DOI:10.1016/0223-5234(91)90024-H