2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide

Base Information

• Chemical Name: 2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide
• CAS No.: 75889-24-6
• Molecular Formula: C₂₄H₂₉N₃O₃
• Molecular Weight: 407.513

Synonyms:2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide

Chemical Property of 2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide

Chemical Property:

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Technology Process of 2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide

There total 2 articles about 2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-phthalimidoethyl)-2',6'-xylidine (75889-19-9) → 2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide (75889-24-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / NaHCO₃ / acetone / 1.5 h / Heating

2: 75 percent / NaI / acetone / Heating

3: ethanol / 16 h / Heating

With sodium hydrogencarbonate; sodium iodide; In ethanol; acetone;

DOI:10.1021/jm00133a012

Reference yield:

N-(2-phthalimidoethyl)-2-iodoaceto-2',6'-xylidide (75889-22-4) + diethylamine (109-89-7) → 2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide (75889-24-6)

Guidance literature:

In ethanol; for 16h; Heating;

DOI:10.1021/jm00133a012

Reference yield: 27.0%

2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-acetamide (75889-24-6) → N-aminophthalamide (1875-48-5) + N-(2-aminoethyl)-2-(diethylamino)aceto-2',6'-xylidide dihydrochloride (75889-40-6)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In ethanol; Heating; 1.) 3 h, 2.) 1 h;

DOI:10.1021/jm00133a012

upstream raw materials:

N-(2-phthalimidoethyl)-2-iodoaceto-2',6'-xylidide

diethylamine

N-(2-phthalimidoethyl)-2',6'-xylidine

Downstream raw materials:

N-aminophthalamide

N-(2-aminoethyl)-2-(diethylamino)aceto-2',6'-xylidide dihydrochloride

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