((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

Base Information

Chemical Name:((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate
CAS No.:956139-30-3
Molecular Formula:C₃₁H₃₄ClN₄O₅P
Molecular Weight:609.062
Hs Code.:
European Community (EC) Number:851-211-7,863-368-9
UNII:6V6D3B7TLJ
Nikkaji Number:J3.138.019G

Synonyms:956139-30-3;((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate;((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl (R)-dimethylphosphoramidochloridate;2077093-78-6;N,N-Dimethylphosphoramidochloridic Acid [(2S,6R)-6-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl Ester;MORPHOLINO T SUBUNIT;6V6D3B7TLJ;ZB1830;Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester;E73718;((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl (S)-dimethylphosphoramidochloridate;[(2S,6R)-6-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate;[(2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl]methyl N,N-dimethylchlorophosphoramidate;1-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-trityl-morpholin-2-yl]-5-methyl-pyrimidine-2,4-dione;1-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-5-methylpyrimidine-2,4-dione;2077093-76-4;6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate, ((2S,6R)-;N,N-Dimethyl-phosphoramidochloridic acid [(2S,6R)-6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester

Suppliers and Price of ((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N,N-DimethylphosphoramidochloridicAcid[(2S,6R)-6-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methylEster
500mg
$ 1540.00

Biosynth Carbosynth
[(2S,6R)-6-{Thymin-1-yl}-4-tritylmorpholin-2-yl]methyl dimethyl-phosphoramidochloridate
5 g
$ 3450.00

Total 13 raw suppliers

Chemical Property of ((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:608.1955349
Heavy Atom Count:42
Complexity:993

Purity/Quality:

99%, ^*data from raw suppliers

N,N-DimethylphosphoramidochloridicAcid[(2S,6R)-6-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CN(CC(O2)COP(=O)(N(C)C)Cl)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2CN(C[C@H](O2)COP(=O)(N(C)C)Cl)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
Uses N,N-Dimethylphosphoramidochloridic Acid [(2S,6R)-6-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl Ester is an oligonucleotide analog having cationic intersubunit linkages for use in antisense modulation of gene expression. Also a potential antibacterial.

Technology Process of ((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

There total 1 articles about ((2S,6R)-6-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 914361-76-5
1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 677-43-0
N,N-dimethylphosphoroamidic dichloride

: 956139-30-3
phosphoramidochloridic acid, N,N-dimethyl-, [6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester

Guidance literature:: 1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide; In dichloromethane; acetonitrile; at 0 ℃; for 0.0333333h; Inert atmosphere;

N,N-dimethylphosphoroamidic dichloride; In dichloromethane; acetonitrile; at 0 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.09.126