677-43-0

Basic information

• Product Name: N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
• Synonyms: N,N-DIMETHYLPHOSPHORAMIC DICHLORIDE;N,N-DIMETHYLPHOSPHORAMIDIC DICHLORIDE;N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE;PHOSPHORIC ACID DIMETHYLAMIDE DICHLORIDE;DIMETHYLAMINOPHOSPHORYL DICHLORIDE;DIMETHYLAMINE PHOSPHORYL DICHLORIDE;DIMETHYLAMIDOPHOSPHORIC DICHLORIDE;DMPADC
• CAS NO: 677-43-0
• Molecular Formula: C₂H₆Cl₂NOP
• Molecular Weight: 161.95
• EINECS: 217-592-3
• Mol File: 677-43-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 77-79 °C11 mm Hg(lit.)
• Flash Point: 89-90°C/20mm
• Appearance: /
• Density: 1.362 g/mL at 20 °C(lit.)
• Vapor Pressure: 1.6mmHg at 25°C
• Refractive Index: n20/D 1.464
• Storage Temp.: 2-8°C
• Solubility: Miscible with dimethoxyethane.
• PKA: -6.60±0.70(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 969956
• CAS DataBase Reference: N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE(677-43-0)
• EPA Substance Registry System: N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE(677-43-0)

Safety Data

• Hazard Codes: C
• Statements: 34-37
• Safety Statements: 26-36/37/39
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• RTECS: TB4025000
• F: 1-3-10
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 677-43-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

Uses

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

InChI:InChI=1/C2H6Cl2NOP/c1-5(2)7(3,4)6/h1-2H3

Upstream product

• 683-85-2 N,N-dimethylaminodichlorophosphane 
• 125029-81-4 N,N-Dimethylamidotetrachlorophosphorane 
• 51-80-9 bis-(dimethylamino)methane 
• 124-40-3 dimethyl amine 
• 1605-65-8 N,N,N',N'-Tetramethylphosphorodiamidic chloride 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 115-26-4 dimefox 
• 1605-65-8 N,N,N',N'-Tetramethylphosphorodiamidic chloride 
• 93310-30-6 N,N-dimethyl-N',N''-diphenyl-phosphamide 
• 63815-55-4 cyano-phosphonic acid dimethylamide-isopropyl ester 
• 2404-04-8 NN-dimethyl di-isopropyl-phosphoramidate 
• 63815-56-5 tabun 
• 65580-47-4 C₁₄H₂₉N₂O₂P 
• 7778-06-5 2-Dimethylamino-2-oxo-1,3-dimethyl-1,3,2-diazaphospholan 
• 117112-19-3 C₈H₁₈ClN₂OP 
• 88946-46-7 2-oxo-2-(dimethylamino)-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 117112-20-6 C₁₁H₂₂ClN₂O₃P 
• 117130-96-8 C₁₁H₂₂ClN₂O₃P 
• 87657-32-7 cis-2-oxo-2-(dimethylamino)-3,5-diphenyl-1,3,2-oxazaphosphorinane 
• 87657-32-7 trans-2-oxo-2-(dimethylamino)-3,5-diphenyl-1,3,2-oxazaphosphorinane 

Relevant articles and documents

REACTION OF 1,1-DICHLORO-1-NITROSOBUTANE WITH N,N-DIMETHYLAMIDODICHLOROPHOSPHITE

-

A cyclic phosphorus method for preparing cooperates the effect halogen-free flame retardant,

The invention relates to a preparation method of a cyclic phosphorus-nitrogen synergistic halogen-free flame retardant, particularly a preparation method of 2,7-di(N,N-dimethylamino)-1,6,3,8,2,7-octahydrodioxadiazolyldiphosphinic acid, belonging to the field of preparation of novel halogen-free flame retardants. The method comprises the following steps: by using an organic solvent as a solvent and alkali as an acid-binding agent, stirring phosphorus oxychloride and dimethylamine hydrochloride to react at -25-0 DEG C until no white precipitate is generated; leaving the low-temperature environment, naturally heating the reaction system to room temperature, and continuing the reaction at room temperature for 2-5 hours; carrying out vacuum filtration to remove the precipitate, thereby obtaining a filtrate; and carrying out secondary heating, and carrying out vacuum filtration to remove the precipitate, thereby obtaining the 2,7-di(N,N-dimethylamino)-1,6,3,8,2,7-octahydrodioxadiazolyldiphosphinic acid. The method has the advantages of simple technique and low cost, can easily implement industrial production, and has wide market application prospects.

Synthesis and antitumor activity of nonsymmetric phosphoric acid triamides

-