677-43-0

Usage

Uses

Used in Chemical Synthesis:
N,N-Dimethylphosphoramidodichloridate is used as a key intermediate for the synthesis of phosphoramidates and (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA), which is employed as a chemical weapon. Its ability to form active intermediates allows it to react with alcohols in situ to produce esters and convert primary alcohols to alkyl chlorides.
Used in Organic Synthesis:
In the field of organic synthesis, N,N-Dimethylphosphoramidodichloridate serves as an important raw material and intermediate. Its reactivity and ability to form active intermediates make it a valuable component in the development of various organic compounds.
Used in Pharmaceuticals:
N,N-Dimethylphosphoramidodichloridate is used as a crucial intermediate in the pharmaceutical industry. Its involvement in the synthesis of various pharmaceutical compounds contributes to the development of new drugs and treatments.
Used in Agrochemicals:
In the agrochemical industry, N,N-Dimethylphosphoramidodichloridate plays a significant role as a raw material and intermediate. Its use in the synthesis of agrochemical products helps in the development of effective solutions for agricultural applications.
Used in Dye Industry:
N,N-Dimethylphosphoramidodichloridate is also utilized in the dye industry as a key intermediate. Its reactivity and ability to form active intermediates contribute to the production of various dyes and pigments.
Additionally, N,N-Dimethylphosphoramidodichloridate reacts with 1,2 diols to prepare cyclic phosphoric amides, which can be further reduced to produce alkenes, expanding its applications in various chemical reactions and processes.

InChI:InChI=1/C2H6Cl2NOP/c1-5(2)7(3,4)6/h1-2H3

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 1605-65-8 N,N,N',N'-Tetramethylphosphorodiamidic chloride 
• 124-40-3 dimethyl amine 
• 51-80-9 bis-(dimethylamino)methane 
• 683-85-2 N,N-dimethylaminodichlorophosphane 
• 125029-81-4 N,N-Dimethylamidotetrachlorophosphorane 

Downstream Products

• 115-26-4 dimefox 
• 1605-65-8 N,N,N',N'-Tetramethylphosphorodiamidic chloride 
• 93310-30-6 N,N-dimethyl-N',N''-diphenyl-phosphamide 
• 62729-72-0 N,N-dimethyl-N',N'-diphenylphosphorodihydrazidic 
• 63815-55-4 cyano-phosphonic acid dimethylamide-isopropyl ester 
• 2404-04-8 NN-dimethyl di-isopropyl-phosphoramidate 
• 110055-68-0 phosphoric acid-chloride dimethylamide-(3-dimethylamino-phenyl ester) 
• 63815-56-5 tabun 
• 77-81-6 tabun 
• 2404-03-7 diethyl N,N-dimethylphosphoramide 
• 56185-11-6 phenyl N,N-dimethyl phosphoroamidochloridate 
• 56185-00-3 dimethyl-amidophosphoric acid di-o-tolyl ester 
• 7291-33-0 2,2,2-trichloro-N,N-dimethylacetamide 
• 354-43-8 N,N-dimethylphosphoramidic difluoride 

Relevant academic research and scientific papers

Amido phosphate bis-curcumin ester compound, preparation method and application

The invention discloses an amido phosphate bis-curcumin ester compound, a preparation method and application, and belongs to the field of medicinal chemistry. The compound has the structural formula as follows (referring to the description). The R1 and R2 in the formula (I) can form a saturated nitrogen heterocyclic ring structure as follows through cyclization (referring to the description). The preparation method of the compound comprises the following steps: firstly, preparing amino phosphoryl chloride or thio amino phosphoryl chloride; then reacting with curcumin to obtain the compound. The amido phosphate bis-curcumin ester compound provided by the invention has relatively good antineoplastic activity, the toxicity of the compound is smaller than that of cisplatin, and the compound can be used for preparing medicine for resisting lung cancer, stomach cancer, leukemia, breast cancer and inflammation.

A cyclic phosphorus method for preparing cooperates the effect halogen-free flame retardant,

The invention relates to a preparation method of a cyclic phosphorus-nitrogen synergistic halogen-free flame retardant, particularly a preparation method of 2,7-di(N,N-dimethylamino)-1,6,3,8,2,7-octahydrodioxadiazolyldiphosphinic acid, belonging to the field of preparation of novel halogen-free flame retardants. The method comprises the following steps: by using an organic solvent as a solvent and alkali as an acid-binding agent, stirring phosphorus oxychloride and dimethylamine hydrochloride to react at -25-0 DEG C until no white precipitate is generated; leaving the low-temperature environment, naturally heating the reaction system to room temperature, and continuing the reaction at room temperature for 2-5 hours; carrying out vacuum filtration to remove the precipitate, thereby obtaining a filtrate; and carrying out secondary heating, and carrying out vacuum filtration to remove the precipitate, thereby obtaining the 2,7-di(N,N-dimethylamino)-1,6,3,8,2,7-octahydrodioxadiazolyldiphosphinic acid. The method has the advantages of simple technique and low cost, can easily implement industrial production, and has wide market application prospects.

Synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads

An efficient and operationally simple method is developed for the syndesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In me reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.

Ozonization: An Efficient Method for the Oxidation of Halophosphines

The ozonization of various halophosphines 1a-j leads with quantitative yields to the corresponding phosphine oxides 2a-j.Ozonization is a convenient method of oxidation, in particular of compounds with bulky ligands (1c, 1d, 1e).

Process for the manufacture of phosphoric acid-tris-(dimethylamide)

Process for the manufacture of phosphoric acid-tris-(dimethylamide) (C) by reacting phosphorus oxychloride and dimethylamine in a molar ratio of 1 to at least 3, under anhydrous conditions and, optionally, under the application of pressure, which comprises carrying out the reaction in two separate process stages, wherein, in the first stage the phosphorus oxychloride and dimethylammonium chloride are heated in a molar ratio of approximately 1 : 1.5, and in the second stage dimethylamine is added to a mixture containing about 1.5 gram atoms of chlorine bonded to phosphorus and consisting of phosphoric acid dimethylamide-dichloride (A) and phosphoric acid-bis-(dimethylamide)-chloride (B) in which the proportion of (A) is not more than 50 mole %, or added to B alone, C is separated off at the end of the amine absorption and the formed dimethylammonium chloride is returned to the first stage. The compound C produced is a valuable polar solvent and reaction medium with catalytic properties which is being used increasingly as an intermediate product.