5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid

Base Information

Chemical Name:5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid
CAS No.:1204220-87-0
Molecular Formula:C₅₀H₄₉ClO₇
Molecular Weight:797.388
Hs Code.:

Synonyms:5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid

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Chemical Property of 5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid

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Technology Process of 5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid

There total 16 articles about 5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1061314-50-8
(5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)-phenyl)methanol

: 1204220-87-0
5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid

Guidance literature:: With Jones reagent; In acetone; at 0 - 20 ℃; for 6h;

Reference yield:

: 1204220-85-8
5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)benzaldehyde

: 1204220-87-0
5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid

Guidance literature:: With sodium perchlorate; dihydrogen peroxide; In water; tert-butyl alcohol; at 20 ℃;

Reference yield:

: 1061314-06-4
[2-bromo-5-chloro-4-(4-ethylbenzyl)phenyl]methanol

: 1204220-87-0
5-chloro-4-(4-ethylbenzyl)-2-[(2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - -45 °C / Inert atmosphere

2.3: 2 h / -25 - 5 °C / Inert atmosphere

3.1: acetic acid; sodium acetate; palladium dichloride / water / 1.5 h / 75 °C

4.1: Jones reagent / acetone / 6 h / 0 - 20 °C

With Jones reagent; n-butyllithium; sodium acetate; sodium hydride; acetic acid; palladium dichloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetone; mineral oil;