Technology Process of C45H56F2N4O9S
There total 7 articles about C45H56F2N4O9S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
NH2-D-Lys(Boc)-Ot-Bu*HCl; N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-valine;
With
4-methyl-morpholine;
In
dichloromethane;
for 0.0833333h;
With
(1,1,1-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate;
In
dichloromethane;
NH2-D-Lys(Boc)-Ot-Bu*HCl;
With
4-methyl-morpholine; (1,1,1-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate;
In
dichloromethane;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: formic acid / 5 h / 50 °C
2.1: 4-methyl-morpholine / dichloromethane / 0.08 h
2.3: 2 h
With
4-methyl-morpholine; formic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: toluene / 23 h / Heating / reflux
2.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.08 h / 0 °C
2.2: 0.33 h / -40 - 0 °C
3.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C
3.2: 18 h / 45 °C
3.3: 6 h / 45 °C
4.1: dichloromethane / 2 h / 0 °C
5.1: tributylphosphine; water / acetone / 0.5 h / 20 °C
5.2: 1.5 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C
7.1: 4-methyl-morpholine / dichloromethane / 0.08 h
8.1: formic acid / 5 h / 50 °C
9.1: 4-methyl-morpholine / dichloromethane / 0.08 h
9.3: 2 h
With
4-methyl-morpholine; titanium(IV) isopropylate; formic acid; tributylphosphine; water; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; trifluoroacetic acid;
In
dichloromethane; acetone; toluene;
