tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate

Base Information

• Chemical Name: tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate
• CAS No.: 436156-61-5
• Molecular Formula: C₂₅H₃₂ClNO₆
• Molecular Weight: 477.985
• Mol file: 436156-61-5.mol

Synonyms:tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate

Chemical Property of tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate

There total 4 articles about tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloroacetyl chloride (79-04-9) + tert-butyl N-(3,4,5-trimethoxy)benzyl-L-phenylalaninate (436156-44-4) → tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate (436156-61-5)

Guidance literature:

With methyloxirane; In tetrahydrofuran; at 20 ℃;

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate (436156-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / methanol / 2 h / 20 °C

2: NaBH₄ / methanol / 2 h / 20 °C

3: 96 percent / propylene oxide / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; TEA; methyloxirane; In tetrahydrofuran; methanol;

Reference yield:

L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) → tert-butyl N-(3,4,5-trimethoxy)benzyl-N-chloroacetyl-L-phenylalaninate (436156-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / methanol / 2 h / 20 °C

2: NaBH₄ / methanol / 2 h / 20 °C

3: 96 percent / propylene oxide / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; TEA; methyloxirane; In tetrahydrofuran; methanol;

upstream raw materials:

chloroacetyl chloride

tert-butyl N-(3,4,5-trimethoxy)benzyl-L-phenylalaninate

3,4,5-trimethoxy-benzaldehyde

L-phenylalanine tert-butyl ester hydrochloride

Downstream raw materials:

4-benzyl-4-tert-butoxycarbonyl-2-azetidinone

4-benzyl-1-(3,4,5-trimethoxy)benzyl-4-tert-butoxycarbonyl-2-azetidinone