γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

Base Information

Chemical Name:γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt
CAS No.:87136-47-8
Molecular Formula:C₇H₈O₃S*C₃₅H₆₂N₆O₁₂
Molecular Weight:931.115
Hs Code.:

Synonyms:γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

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Chemical Property of γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

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Technology Process of γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

There total 5 articles about γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60686-50-2,60686-52-4
N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-L-γ-carboxyglutamic acid

: 87136-47-8
γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide / ethyl acetate / 1.) 0 deg C, 2 h, 2.) RT, overnight

2: 85 percent / trifluoroacetic acid, N-methylmorpholine / dimethylformamide / 48 h / Ambient temperature

3: N-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) 0-4 deg C, 24h, acetonitrile, 2.) H₂O, ethyl acetate

4: Pd/C / methanol; formic acid / 1 h / Ambient temperature

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; formic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00170a015

Reference yield:

: 64153-37-3
N-Benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-N'-Succinimidoyl Ester

: 87136-47-8
γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / trifluoroacetic acid, N-methylmorpholine / dimethylformamide / 48 h / Ambient temperature

2: N-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) 0-4 deg C, 24h, acetonitrile, 2.) H₂O, ethyl acetate

3: Pd/C / methanol; formic acid / 1 h / Ambient temperature

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; formic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00170a015

Reference yield:

: 87136-42-3
N-Benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-arginine

: 87136-47-8
γ,γ-Di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

Guidance literature:: Multi-step reaction with 2 steps

1: N-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) 0-4 deg C, 24h, acetonitrile, 2.) H₂O, ethyl acetate

2: Pd/C / methanol; formic acid / 1 h / Ambient temperature

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; formic acid;
DOI:10.1021/jo00170a015