ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate

Base Information

• Chemical Name: ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate
• CAS No.: 1160431-42-4
• Molecular Formula: C₁₉H₂₀F₂N₂O₃
• Molecular Weight: 362.376

Synonyms:ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate

Chemical Property of ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate

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Technology Process of ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate

There total 1 articles about ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

→ ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate (1160431-42-4)

Guidance literature:

Reference yield: 68.0%

ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate (1160431-42-4) + 4-bromo-2-methylbenzyl bromide (156001-49-9) → ethyl 1-(6-(2-((4-bromo-2-methylbenzyl)oxy)-3,5-difluorophenyl)pyridin-2-yl)piperidine-4-carboxylate (1160431-71-9)

Guidance literature:

With caesium carbonate; In acetone; at 70 ℃; for 16h;

Reference yield: 66.6%

ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate (1160431-42-4) + tert-butyl 4-(5-(hydroxymethyl)-6-methylpyridin-2-yl)piperidine-1-carboxylate → tert-butyl 4-(5-((2-(6-(4-(ethoxycarbonyl)piperidin-1-yl)pyridin-2-yl)-4,6-difluorophenoxy)methyl)-6-methylpyridin-2-yl)piperidine-1-carboxylate

Guidance literature:

ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate; tert-butyl 4-(5-(hydroxymethyl)-6-methylpyridin-2-yl)piperidine-1-carboxylate; With triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

With diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 16.25h;

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