Technology Process of trans-methyl 4-oxo-2-phenylchromane-3-carboxylate
There total 7 articles about trans-methyl 4-oxo-2-phenylchromane-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; sodium iodide / acetone / 0.08 h / 20 °C / Inert atmosphere
1.2: 24 h / 65 °C
2.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.17 h / 0 - 20 °C / Inert atmosphere
2.2: 6 h / Reflux
3.1: p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 3 h / 20 °C
4.1: Rh2[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4 / toluene / 1.5 h / 0 °C / Inert atmosphere
5.1: chromium(VI) oxide; periodic acid / acetonitrile / 1 h / 20 °C
With
chromium(VI) oxide; p-nitrobenzenesulfonyl azide; Rh2[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; periodic acid; sodium iodide;
In
1,2-dimethoxyethane; dichloromethane; acetone; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.tet.2011.03.004
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Rh2[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4 / toluene / 1.5 h / 0 °C / Inert atmosphere
2: chromium(VI) oxide; periodic acid / acetonitrile / 1 h / 20 °C
With
chromium(VI) oxide; Rh2[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; periodic acid;
In
toluene; acetonitrile;
DOI:10.1016/j.tet.2011.03.004
