20349-89-7

Usage

Uses

Used in Fragrance and Flavor Industry:
METHYL 3-(2-HYDROXYPHENYL)PROPIONATE is used as a fragrance and flavoring agent for its pleasant, sweet, and slightly floral scent. It is incorporated into the formulation of perfumes, soaps, and other scented household products to enhance their aroma.
Used in Food and Beverage Industry:
In the food and beverage industry, METHYL 3-(2-HYDROXYPHENYL)PROPIONATE is used as a flavoring agent to impart a unique taste and aroma to various food products and beverages, contributing to their overall sensory appeal.
Used in Medicinal Applications:
METHYL 3-(2-HYDROXYPHENYL)PROPIONATE is studied for its potential medicinal properties, such as anti-inflammatory and antioxidant effects. Its therapeutic potential is being explored for various health applications, highlighting its significance in the pharmaceutical sector.

InChI:InChI=1/C10H12O3/c1-13-10(12)7-6-8-4-2-3-5-9(8)11/h2-5,11H,6-7H2,1H3

Upstream product

• 67-56-1 methanol 
• 495-78-3 3-(2-hydroxyphenyl)propionic acid 
• 186581-53-3 diazomethane 
• 83-33-0 inden-1-one 
• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 91-64-5 coumarin 
• 74-88-4 methyl iodide 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 90-02-8 salicylaldehyde 
• 6236-69-7 methyl 2-hydroxycinnamate 
• 100-52-7 benzaldehyde 
• 42251-12-7 α-nitro cinnamate de methyle E 
• 40149-56-2 Methyl α-nitro-β-phenylpropionate 
• 77086-38-5 ketene t-butyldimethylsilyl methyl acetal 

Downstream Products

• 141773-81-1 3-[2-[6-(4-methoxyphenyl)(5E)-5-hexenyloxy]-phenyl]-propionic acid methyl ester 
• 150597-60-7 2-[(5-bromopentyl)oxy]benzenepropanoic acid methyl ester 
• 150598-25-7 2-[(5-hexynyl)oxy]benzenepropanoic acid methyl ester 
• 150597-81-2 2-[3-(chloromethyl)phenylmethoxy]benzenepropanoic acid methyl ester 
• 108495-51-8 methyl 3-(2-N,N-dimethylthiocarbamoyloxyphenyl)propionate 
• 1097104-24-9 tert-butyl (2S,3S)-2-[α-(2-(3-methoxy-3-oxopropyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate 
• 220285-28-9 3-(2-ethoxyphenyl)propionic acid 
• 936329-18-9 methyl 3-(2-(3-chloropropoxy)phenyl)propanoate 
• 327189-16-2 methyl 3-[2-[3-[4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolyl]propoxy]phenyl]propionate 
• 83281-63-4 3-[2-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester 
• 722539-55-1 methyl 3-(2-hydroxy-3-hydroxymethyl-phenyl)propionate 
• 56052-50-7 methyl 3-[2-(benzyloxy)phenyl]propanoate 
• 374626-54-7 3-(2-{2-[4-(4-chloro-benzyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-propionic acid methyl ester 
• 67-56-1 methanol 

Relevant academic research and scientific papers

Microbial reduction of coumarin, psoralen, and xanthyletin by Glomerella cingulata

Microbial transformation of coumarin, psoralen, and xanthyletin was performed with the fungus Glomerella cingulata. The main reaction pathways involved reduction at α,β-unsaturated δ-lactone ring on coumarin analogue. Coumarin was metabolized by G. cingul

Celite-Polyaniline supported palladium catalyst for chemoselective hydrogenation reactions

Polyaniline coated on particles of celite is used as support to load palladium catalyst. This heterogenized Celite?PANI?Pd system, is used as an efficient catalyst for chemoselective hydrogenation reactions. The catalyst is characterized by usual spectral, analytical techniques and studied for hydrogenation reactions at ambient conditions. The mild reaction conditions allow the control over the reactions and excellent selectivity is achieved in number of conversions. Hydrogenation of a carbon–carbon double bond was favored over other polar π-bond systems, while labile functional groups such as benzyl ether, benzyl esters, cyano, nitro and halogen remained unaffected. Primary amines were converted to N,N-dimethyl amines with formaldehyde, the double bond of coumarin was selectively hydrogenated without opening of the lactone functionality.

LYSOPHOSPHATIDYLSERINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a lysophosphatidylserine derivative or salt thereof. SOLUTION: The present invention provides a lysophosphatidylserine derivative or salt thereof, or a pharmaceutical composition or lysophosphatidylserine receptor function modulator including the compound or salt thereof. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

COMPOUND EXHIBITING REGULATORY ACTIVITY ON LYSOPHOSPHATIDYLSERINE RECEPTOR FUNCTION

The object of the present invention is to provide a compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof. A compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof, or a pharmaceutical composition or a lysophosphatidylserine receptor function moderator containing such compound or salt is provided by the present invention.

Hydrogenation of coumarin to octahydrocoumarin over a Ru/C catalyst

The production of octahydrocoumarin, which can serve as a replacement for toxic coumarin, was investigated using 5% Ru on active carbon (Ru/C) as the catalyst for the hydrogenation of coumarin. The hydrogenation was studied by optimizing the reaction conditions (pressure, solvent and coumarin concentration). The activity and selectivity of the Ru/C catalyst were compared for different solvents. The mechanism of coumarin hydrogenation was deduced. The formation of side products was explained. The optimal hydrogenation reaction conditions were: 130 °C, 10 MPa, 60 wt% coumarin in methanol, and 0.5 wt% (based on coumarin) of Ru/C catalyst. At the complete conversion of coumarin, the selectivity to the desired product was 90%.

Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide

The oxidation of arenes by the reagent phthaloyl peroxide provides a new method for the synthesis of phenols. A new, more reactive arene oxidizing reagent, 4,5-dichlorophthaloyl peroxide, computationally predicted and experimentally determined to possess enhanced reactivity, has expanded the scope of the reaction while maintaining a high level of tolerance for diverse functional groups. The reaction proceeds through a novel "reverse-rebound" mechanism with diradical intermediates. Mechanistic insight was achieved through isolation and characterization of minor byproducts, determination of linear free energy correlations, and computational analysis of substituent effects of arenes, each of which provided additional support for the reaction proceeding through the diradical pathway.

Small molecule inhibitors of anthrax lethal factor toxin

This manuscript describes the preparation of new small molecule inhibitors of Bacillus anthracis lethal factor. Our starting point was the symmetrical, bis-quinolinyl compound 1 (NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more drug-like compounds.

CYCLIC PEROXIDE OXIDATION OF AROMATIC COMPOUND PRODUCTION AND USE THEREOF

The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C-H bonds and one or more activated C-H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C-H bonds; oxidizing selectively one of the one or more aromatic C-H bonds in preference to the one or more activated C-H bonds; adding a hydroxyl group to the one of the one or more aromatic C-H bonds to form one or more phenols; and purifying the one or more phenols.

Biotransformation of dihydrocoumarin by Aspergillus niger ATCC 11394

Aspergillus niger ATCC 11394 was used to catalyze the biotransformation of dihydrocoumarin using two experimental conditions: growing and resting cells. Six biotransformation products (2- 7) were purified from the bio-reaction media and their structures e

Solvent influence in the Rh-catalyzed intramolecular 1,6 C-H insertions: A general approach to the chromane and flavanone skeletons

Solvent polarity and nature of the ligands on the catalyst are crucial factors that control the regioselectivity of the Rh(II) promoted intramolecular 1,6 C-H insertions versus the β-elimination. We have explored the best conditions for the preparation of flavanones and chromenes through this approach. The procedure is also an excellent way of preparing stereochemically pure Z aryl-alkenes.