3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone

Base Information

Chemical Name:3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone
CAS No.:851777-08-7
Molecular Formula:C₁₉H₁₈Br₂O₇
Molecular Weight:518.156
Hs Code.:

Synonyms:3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone

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Chemical Property of 3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone

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Technology Process of 3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone

There total 2 articles about 3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2973-77-5
3,5-dibromo-4-hydroxybenzaldehyde

: 65490-09-7
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

: 851777-08-7
3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; ethanol; at 20 - 40 ℃; for 40h;
DOI:10.1021/jf047897u

Reference yield:

: 480-66-0,67471-34-5
2,4,6-trihydroxyacetophenone

: 851777-08-7
3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / K₂CO₃ / acetone / 1 h / Heating

2: 77 percent / KOH / ethanol; tetrahydrofuran / 40 h / 20 - 40 °C

With potassium hydroxide; potassium carbonate; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jf047897u

Reference yield:

: 851777-08-7
3-(3,5-dibromo-4-hydroxyphenyl)-1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)propenone

: (2S)-(-)-2-(3,5-ditrityl-4-hydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)chroman-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: 35 percent / HCl / methanol / 1 h / Heating

2: 69 percent / sodium acetate / methanol / 3 h / Heating

3: 83 percent / pyridine / 1.5 h / 20 °C

4: 57 percent / PPh₃; DIAD / tetrahydrofuran / 2 h / 20 °C

5: 81 percent / Eu[FOD]3 / CHCl₃ / 20 h / 60 °C

6: 98 percent / aq. K₂CO₃ / methanol / 3 h / 40 °C

7: 84 percent / aq. K₂CO₃ / methanol / 18 h / 40 °C

8: tritium; Et₃N / Pd/C / ethyl acetate / 16 h

With pyridine; hydrogenchloride; tritium; di-isopropyl azodicarboxylate; sodium acetate; potassium carbonate; triethylamine; triphenylphosphine; Eu(fod)3; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; ethyl acetate; 4: Mitsunobu reaction;
DOI:10.1021/jf047897u