N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Base Information

Chemical Name:N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester
CAS No.:159579-65-4
Molecular Formula:C₂₉H₃₂N₄O₇
Molecular Weight:548.596
Hs Code.:

Synonyms:N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

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Technology Process of N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

There total 4 articles about N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 159579-65-4
N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Bu₄NI

2: 89 percent / H₂ / 10percent Pd-C / ethanol / 0.25 h

3: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1.3 h, 2.) room temp., 20 min

With hydrogen; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo00088a010

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 159579-65-4
N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / aq. Na₂CO₃

2: 87 percent / Bu₄NI

3: 89 percent / H₂ / 10percent Pd-C / ethanol / 0.25 h

4: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1.3 h, 2.) room temp., 20 min

With hydrogen; tetra-(n-butyl)ammonium iodide; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo00088a010

Reference yield:

: 159579-79-0
(R)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid 2-methoxy-ethoxymethyl ester

: 159579-65-4
N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / H₂ / 10percent Pd-C / ethanol / 0.25 h

2: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1.3 h, 2.) room temp., 20 min

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo00088a010