6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid

Base Information

Chemical Name:6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid
CAS No.:1395281-28-3
Molecular Formula:C₂₀H₂₄F₃NO₄Si
Molecular Weight:427.496
Hs Code.:

Synonyms:6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid

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Technology Process of 6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid

There total 7 articles about 6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1395281-25-0
methyl 6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

: 1395281-28-3
6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid

Guidance literature:

Reference yield: 87.0%

: 1395281-28-3
6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid

Guidance literature:

Reference yield:

: 374633-36-0
2-bromo-3-fluoro-6-methylpyridine

: 1395281-28-3
6-(3-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium permanganate / water

2: sulfuric acid / methanol

3: nitrogen; potassium fluoride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; tetrahydrofuran

4: palladium-carbon / ethyl acetate; methanol

5: caesium carbonate / N,N-dimethyl-formamide

With potassium permanganate; potassium fluoride; sulfuric acid; nitrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium-carbon; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;